Ghani 2006.
| Methods | Country: Malaysia Setting: single centre Time frame: not stated Parallel RCT Intention‐to‐treat analysis: yes Follow‐up period: not stated Lost to follow‐up: 0/33 |
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| Participants | No. of participants randomized: 33 No. of participants analysed: 33 3 participants excluded on account of inadequate blood sample collection Treatment intervention N = 15 Mean age: 58 years Male, %: 53.33 Pre‐existing CKD: 40% Diabetes: 46.66% Baseline MAP: 99.3 mmHg Control intervention N = 18 Mean age: 57.50 years Male, %: 61.11 Pre‐existing CKD: 50.00% Diabetes: 50.00% Baseline MAP: 87.6 mmHg Inclusion criteria Patients who fulfilled criteria for sepsis (study author’s definition) with 1 additional major end‐organ dysfunction or septic shock as defined by the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Exclusion criteria ESRD (end‐stage renal disease) Underlying malignancy AIDS Life expectancy < 6 months |
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| Interventions |
Treatment intervention 6 hours of HVHF Ultrafiltration rate: 6 L/h (equivalent to 100 mL/kg/h, whichever was higher) Blood flow: 250–350 mL/min Bicarbonate substitution fluid 1.4 m2 polyethersulfone dialysis membrane Control intervention 6 hours of CVVH Ultrafiltration rate: 2 L/h (equivalent to almost 35 mL/kg/h) Blood flow: 200‐250 mL/min 1.4 m2 polyethersulfone dialysis membrane |
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| Outcomes | Blood pressure (systolic, diastolic and mean arterial pressure) SOFA scores |
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| Notes | Funding source: Edwards Life Sciences No conflicts of interest declared |
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| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | Block randomization carried out |
| Allocation concealment (selection bias) | Unclear risk | Insufficient information available |
| Blinding of participants and personnel (performance bias) All outcomes | Low risk | Not possible to blind personnel to allocated treatment, although considered to be at low risk |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Insufficient information available to comment |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Insufficient information available to comment |
| Selective reporting (reporting bias) | Low risk | Protocol available and predefined outcomes reported |
| Other bias | Low risk | Appears to be free of other sources of bias |