| Study | Reason for exclusion |
|---|---|
| Abe 2010 | Type of participant not appropriate (not all septic) |
| Bellomo 2009 | Type of participant not appropriate (not all septic) |
| Bouman 2002 | Type of participant not appropriate (not all septic) |
| Bouman 2007 | Review paper, not a trial report |
| Castro 2008 | Study design not appropriate (an algorithm for use in emergency room) |
| Chu 2013 | Type of participant not appropriate (not all septic) |
| Clark 2014 | Review paper, not a trial report |
| Cole 2003 | Outcome measures not appropriate (outcomes focused on acid base measurements) |
| Combes 2015 | Type of participant not appropriate (not all septic) |
| Guo 2014 | Type of participant not appropriate (not all septic) |
| Haase 2007 | Type of intervention not appropriate (high adsorption filters under investigation, not HVHF) |
| Han 2011 | Outcome measures not appropriate (outcomes focused on endothelial cell function) |
| Hoffman 1996 | Type of intervention not appropriate (not HVHF) |
| Honore 2003 | Review paper, not a trial report |
| Honore 2004 | Review paper, not a trial report |
| Honore 2007 | Review paper, not a trial report |
| Honore 2009 | Review paper, not a trial report |
| Mao 2009 | Type of intervention not appropriate (not HVHF, plasma adsorption under investigation) |
| Morgera 2006 | Type of intervention not appropriate (not HVHF, high cut‐off filters under investigation) |
| Oudemans‐van Straaten1999 | Type of participant and study design not appropriate (not all septic, not randomized) |
| Palevsky 2008 | Type of participant not appropriate (not all septic) |
| Payen 2009 | Type of intervention not appropriate (not HVHF) |
| Peng 2010 | Outcome measures not appropriate (outcomes focused on cytokine levels) |
| Quenot 2015 | Type of intervention not appropriate (extra high volume haemofiltration vs HVHF) |
| Ronco 2000 | Type of participant not appropriate (not all septic) |
| Storck 1991 | Type of participant and intervention not appropriate (not all septic, not HVHF) |
| Wang 2009 | Outcome measures not appropriate (outcomes focused on lactic acid and cytokine levels) |
| Xie 2009 | Type of participant not appropriate (not all septic) |
| Yu 2008 | Type of participant not appropriate (not septic, all pancreatitis) |
| Zainudin 2006 | Abstract only, published paper included (different first study author) |
| Zhang 2004 | Outcome measures not appropriate (outcomes focused on cytokine levels) |
| Zhang 2012 | Type of intervention not appropriate (extra high volume haemofiltration vs HVHF) |
HVHF: high‐volume haemofiltration.