| Methods |
Double‐blind, placebo controlled trial. |
| Participants |
10 female, 1 male, mean age 68 years old with open fungating primary or metastatic tumours (9 breast, 1 ovarian, 1 lung) that produced an offensive odour graded at least 6/10 on a visual analogue scale (where 0 = no odour). |
| Interventions |
0.8% metronidazole gel 1 g/cm2 lesion applied daily. |
| Outcomes |
Reduction of odour. |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
The report states that this was a 'randomised placebo controlled trial' but the method of generating the randomisation sequence was not described. |
| Allocation concealment (selection bias) |
Unclear risk |
not reported |
| Blinding (performance bias and detection bias)
outcome assessment |
Unclear risk |
The report states that this was a double‐blind... trial' but who was blinded was not reported. |
| Incomplete outcome data (attrition bias)
All outcomes |
Unclear risk |
The report states that two patients withdrew from the study, one from each treatment group. It was not stated whether an ITT analysis was conducted. |
