Creinin 1997

Methods	Sealed, numbered, sequential envelopes containing instructions based on computer‐generated random number table.
Participants	20 women with non‐viable pregnancies diagnosed by transvaginal ultrasound; < 9 weeks; closed cervix; no contra‐indication to misoprostol; no heavy bleeding.
Interventions	400 mcg misoprostol orally, repeated after 24 hours if the pregnancy had not been expelled (n = 12); vaginal misoprostol 800 mcg ‐ repeated after 24 hours if necessary (as above) (n = 8). Surgical evacuation offered to women in both groups after 48 hours if treatment unsuccessful.
Outcomes	Miscarriage; pain (visual analogue scale); side‐effects.
Notes	Pilot study.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Low risk	A ‐ Adequate