Demetroulis 2001
| Methods | Randomisation by opening sealed opaque envelope containing computer generated allocation code number. No attempt at masking given the manifest differences between medical and surgical interventions. | |
| Participants | 80 women with incomplete miscarriage or anembryonic pregnancy or missed miscarriage < 13 weeks, diagnosed by ultrasound. The data in this review are derived only from the subgroup with non‐viable pregnancies (n = 50) and not those with incomplete miscarriages. Women were reviewed 8‐10 hours after medical treatment; if they had empty uteruses on ultrasound examination they were discharged home; if not, surgical evacuation was arranged. | |
| Interventions | Vaginal misoprostol 800 mcg once only (n = 26) versus surgical evacuation of the uterus (n = 24). | |
| Outcomes | Need for surgical evacuation, symptoms including pain and bleeding, 'satisfaction'. | |
| Notes | Authors contacted for information on outcomes according to indication for treatment. Only usable data currently available are on incidence of surgical evacuation. | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Allocation concealment (selection bias) | Low risk | A ‐ Adequate |