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. 2006 Jul 19;2006(3):CD002253. doi: 10.1002/14651858.CD002253.pub3

Demetroulis 2001

Methods Randomisation by opening sealed opaque envelope containing computer generated allocation code number. No attempt at masking given the manifest differences between medical and surgical interventions.
Participants 80 women with incomplete miscarriage or anembryonic pregnancy or missed miscarriage < 13 weeks, diagnosed by ultrasound. The data in this review are derived only from the subgroup with non‐viable pregnancies (n = 50) and not those with incomplete miscarriages. Women were reviewed 8‐10 hours after medical treatment; if they had empty uteruses on ultrasound examination they were discharged home; if not, surgical evacuation was arranged.
Interventions Vaginal misoprostol 800 mcg once only (n = 26) versus surgical evacuation of the uterus (n = 24).
Outcomes Need for surgical evacuation, symptoms including pain and bleeding, 'satisfaction'.
Notes Authors contacted for information on outcomes according to indication for treatment. Only usable data currently available are on incidence of surgical evacuation.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Low risk A ‐ Adequate