Lister 2005

Methods	Random allocation ‐ blocked and stratified by physician office and by day of recruitment ‐ day of diagnosis, or after day of diagnosis.
Participants	34 women in Columbus, Ohio, USA, with early pregnancy failure (anembryonic pregnancies or early fetal deaths) diagnosed by TVS.
Interventions	Vaginal misoprostol 800 mcg, repeated after 24 hours if sac still present on TVS (n = 18) or placebo (n = 16).
Outcomes	Primary: miscarriage complete at 48 hours.
Notes	Planned sample size 84 but trial stopped after interim analysis of first 36 women. Two women excluded from analysis ‐ one protocol violation; one did not meet entry criteria. Two women did not come for assessment 2 weeks after initial treatment.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Low risk	A ‐ Adequate