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. 2006 Jul 19;2006(3):CD002253. doi: 10.1002/14651858.CD002253.pub3

Muffley 2002

Methods Computer‐generated random number table with blocked permutations ‐ group assignments recorded in sealed opaque numbered envelopes.
Participants 50 women with non‐viable pregnancies diagnosed by ultrasound (anembryonic or embryonic/fetal deaths) < 12 weeks. Exclusions: excessive bleeding, anaemia, unstable vital signs, coagulopathy, asthma or other contra‐indication to prostaglandin treatment, infection, open cervix.
Interventions 800 mcg misoprostol vaginally, repeated after 24 hours if ultrasound showed tissue still present in uterus; final review after further 24 hours ‐ if tissue still present, surgical evacuation performed (n = 25). Suction curettage (n = 25).
Outcomes Primary outcome: miscarriage.
Notes Analysis by intention to treat. Details about nausea, vomiting, diarrhoea reported only for misoprostol group.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Low risk A ‐ Adequate