Muffley 2002
| Methods | Computer‐generated random number table with blocked permutations ‐ group assignments recorded in sealed opaque numbered envelopes. | |
| Participants | 50 women with non‐viable pregnancies diagnosed by ultrasound (anembryonic or embryonic/fetal deaths) < 12 weeks. Exclusions: excessive bleeding, anaemia, unstable vital signs, coagulopathy, asthma or other contra‐indication to prostaglandin treatment, infection, open cervix. | |
| Interventions | 800 mcg misoprostol vaginally, repeated after 24 hours if ultrasound showed tissue still present in uterus; final review after further 24 hours ‐ if tissue still present, surgical evacuation performed (n = 25). Suction curettage (n = 25). | |
| Outcomes | Primary outcome: miscarriage. | |
| Notes | Analysis by intention to treat. Details about nausea, vomiting, diarrhoea reported only for misoprostol group. | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Allocation concealment (selection bias) | Low risk | A ‐ Adequate |