1 Death |
16 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
1.1 At 3 to 6 months (+ CNI) |
3 |
523 |
Risk Ratio (M‐H, Random, 95% CI) |
0.41 [0.13, 1.22] |
1.2 At 1 to 2 years (+ CNI) |
5 |
632 |
Risk Ratio (M‐H, Random, 95% CI) |
0.75 [0.27, 2.06] |
1.3 At 1 to 2 years (no CNI) |
6 |
621 |
Risk Ratio (M‐H, Random, 95% CI) |
1.03 [0.86, 1.22] |
1.4 At 5 years (+ CNI) |
2 |
159 |
Risk Ratio (M‐H, Random, 95% CI) |
0.94 [0.11, 7.81] |
2 Graft loss (all cause) |
13 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
2.1 At 3 to 6 months (+ CNI) |
4 |
638 |
Risk Ratio (M‐H, Random, 95% CI) |
0.60 [0.34, 1.05] |
2.2 At 1 to 2 years (+ CNI) |
3 |
549 |
Risk Ratio (M‐H, Random, 95% CI) |
0.65 [0.36, 1.19] |
2.3 At 1 to 2 years (no CNI) |
4 |
500 |
Risk Ratio (M‐H, Random, 95% CI) |
0.70 [0.49, 1.01] |
2.4 At 5 years (+ CNI) |
2 |
159 |
Risk Ratio (M‐H, Random, 95% CI) |
1.13 [0.62, 2.05] |
2.5 At 1 to 2 years (all studies) |
7 |
1049 |
Risk Ratio (M‐H, Random, 95% CI) |
0.71 [0.53, 0.95] |
3 Graft loss (death censored) |
10 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
3.1 At 1 to 2 years (+ CNI) |
2 |
82 |
Risk Ratio (M‐H, Random, 95% CI) |
0.57 [0.19, 1.75] |
3.2 At 1 to 2 years (no CNI) |
6 |
299 |
Risk Ratio (M‐H, Random, 95% CI) |
0.55 [0.38, 0.78] |
3.3 at 5 years (+ CNI) |
2 |
148 |
Risk Ratio (M‐H, Random, 95% CI) |
1.64 [0.20, 13.18] |
3.4 At 1 to 2 years (all studies) |
8 |
381 |
Risk Ratio (M‐H, Random, 95% CI) |
0.55 [0.39, 0.77] |
4 Acute rejection |
17 |
2044 |
Risk Ratio (M‐H, Random, 95% CI) |
0.63 [0.51, 0.78] |
4.1 At 1 to 2 years (+ CNI) |
12 |
1491 |
Risk Ratio (M‐H, Random, 95% CI) |
0.61 [0.49, 0.76] |
4.2 At 1 to 2 years (no CNI) |
5 |
553 |
Risk Ratio (M‐H, Random, 95% CI) |
0.65 [0.43, 0.98] |
5 Delayed graft function |
9 |
1304 |
Risk Ratio (M‐H, Random, 95% CI) |
0.93 [0.78, 1.10] |
6 Infection |
13 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
6.1 Any infection |
7 |
824 |
Risk Ratio (M‐H, Random, 95% CI) |
1.05 [0.88, 1.26] |
6.2 CMV infection |
6 |
1072 |
Risk Ratio (M‐H, Random, 95% CI) |
1.55 [1.24, 1.95] |
6.3 Other viral infection (not CMV) |
4 |
664 |
Risk Ratio (M‐H, Random, 95% CI) |
1.11 [0.43, 2.87] |
6.4 Viral infection (all cause) |
3 |
197 |
Risk Ratio (M‐H, Random, 95% CI) |
1.38 [0.56, 3.39] |
6.5 Bacterial infection |
5 |
775 |
Risk Ratio (M‐H, Random, 95% CI) |
1.15 [0.96, 1.37] |
7 Leucopenia |
4 |
920 |
Risk Ratio (M‐H, Random, 95% CI) |
3.86 [2.79, 5.34] |
8 Thrombocytopenia |
4 |
848 |
Risk Ratio (M‐H, Random, 95% CI) |
2.41 [1.61, 3.61] |
9 Malignancy or PTLD |
7 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
9.1 Malignancy at 1 to 2 years (+ CNI) |
3 |
611 |
Risk Ratio (M‐H, Random, 95% CI) |
0.94 [0.22, 3.94] |
9.2 Malignancy at 5 years (+ CNI) |
2 |
159 |
Risk Ratio (M‐H, Random, 95% CI) |
0.94 [0.14, 6.23] |
9.3 Malignancy at 1 to 2 years (no CNI) |
2 |
121 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
9.4 PTLD at 1 to 2 years (+ CNI) |
1 |
151 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
10 Other adverse outcomes |
6 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
10.1 NODAT |
6 |
935 |
Risk Ratio (M‐H, Random, 95% CI) |
1.01 [0.56, 1.84] |
10.2 Serum sickness |
1 |
371 |
Risk Ratio (M‐H, Random, 95% CI) |
60.67 [3.74, 984.93] |
10.3 Tremor |
1 |
371 |
Risk Ratio (M‐H, Random, 95% CI) |
0.93 [0.46, 1.87] |
11 Serum creatinine |
5 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
11.1 At 6 months (+ CNI) |
2 |
503 |
Mean Difference (IV, Random, 95% CI) |
‐5.34 [‐13.44, 2.75] |
11.2 At 1 year (+ CNI) |
2 |
222 |
Mean Difference (IV, Random, 95% CI) |
‐10.56 [‐21.81, 0.69] |
11.3 At 1 year: LD recipients (no CNI) |
1 |
30 |
Mean Difference (IV, Random, 95% CI) |
‐9.70 [‐67.32, 47.92] |
11.4 At 1 year: DD recipients (no CNI) |
1 |
19 |
Mean Difference (IV, Random, 95% CI) |
‐23.0 [‐62.70, 16.70] |
11.5 At 5 years (+ CNI) |
1 |
55 |
Mean Difference (IV, Random, 95% CI) |
‐32.70 [‐68.98, 3.58] |