Comparison 1. ATG versus placebo/no treatment.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Death	16		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 At 3 to 6 months (+ CNI)	3	523	Risk Ratio (M‐H, Random, 95% CI)	0.41 [0.13, 1.22]
1.2 At 1 to 2 years (+ CNI)	5	632	Risk Ratio (M‐H, Random, 95% CI)	0.75 [0.27, 2.06]
1.3 At 1 to 2 years (no CNI)	6	621	Risk Ratio (M‐H, Random, 95% CI)	1.03 [0.86, 1.22]
1.4 At 5 years (+ CNI)	2	159	Risk Ratio (M‐H, Random, 95% CI)	0.94 [0.11, 7.81]
2 Graft loss (all cause)	13		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 At 3 to 6 months (+ CNI)	4	638	Risk Ratio (M‐H, Random, 95% CI)	0.60 [0.34, 1.05]
2.2 At 1 to 2 years (+ CNI)	3	549	Risk Ratio (M‐H, Random, 95% CI)	0.65 [0.36, 1.19]
2.3 At 1 to 2 years (no CNI)	4	500	Risk Ratio (M‐H, Random, 95% CI)	0.70 [0.49, 1.01]
2.4 At 5 years (+ CNI)	2	159	Risk Ratio (M‐H, Random, 95% CI)	1.13 [0.62, 2.05]
2.5 At 1 to 2 years (all studies)	7	1049	Risk Ratio (M‐H, Random, 95% CI)	0.71 [0.53, 0.95]
3 Graft loss (death censored)	10		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 At 1 to 2 years (+ CNI)	2	82	Risk Ratio (M‐H, Random, 95% CI)	0.57 [0.19, 1.75]
3.2 At 1 to 2 years (no CNI)	6	299	Risk Ratio (M‐H, Random, 95% CI)	0.55 [0.38, 0.78]
3.3 at 5 years (+ CNI)	2	148	Risk Ratio (M‐H, Random, 95% CI)	1.64 [0.20, 13.18]
3.4 At 1 to 2 years (all studies)	8	381	Risk Ratio (M‐H, Random, 95% CI)	0.55 [0.39, 0.77]
4 Acute rejection	17	2044	Risk Ratio (M‐H, Random, 95% CI)	0.63 [0.51, 0.78]
4.1 At 1 to 2 years (+ CNI)	12	1491	Risk Ratio (M‐H, Random, 95% CI)	0.61 [0.49, 0.76]
4.2 At 1 to 2 years (no CNI)	5	553	Risk Ratio (M‐H, Random, 95% CI)	0.65 [0.43, 0.98]
5 Delayed graft function	9	1304	Risk Ratio (M‐H, Random, 95% CI)	0.93 [0.78, 1.10]
6 Infection	13		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
6.1 Any infection	7	824	Risk Ratio (M‐H, Random, 95% CI)	1.05 [0.88, 1.26]
6.2 CMV infection	6	1072	Risk Ratio (M‐H, Random, 95% CI)	1.55 [1.24, 1.95]
6.3 Other viral infection (not CMV)	4	664	Risk Ratio (M‐H, Random, 95% CI)	1.11 [0.43, 2.87]
6.4 Viral infection (all cause)	3	197	Risk Ratio (M‐H, Random, 95% CI)	1.38 [0.56, 3.39]
6.5 Bacterial infection	5	775	Risk Ratio (M‐H, Random, 95% CI)	1.15 [0.96, 1.37]
7 Leucopenia	4	920	Risk Ratio (M‐H, Random, 95% CI)	3.86 [2.79, 5.34]
8 Thrombocytopenia	4	848	Risk Ratio (M‐H, Random, 95% CI)	2.41 [1.61, 3.61]
9 Malignancy or PTLD	7		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
9.1 Malignancy at 1 to 2 years (+ CNI)	3	611	Risk Ratio (M‐H, Random, 95% CI)	0.94 [0.22, 3.94]
9.2 Malignancy at 5 years (+ CNI)	2	159	Risk Ratio (M‐H, Random, 95% CI)	0.94 [0.14, 6.23]
9.3 Malignancy at 1 to 2 years (no CNI)	2	121	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
9.4 PTLD at 1 to 2 years (+ CNI)	1	151	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
10 Other adverse outcomes	6		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
10.1 NODAT	6	935	Risk Ratio (M‐H, Random, 95% CI)	1.01 [0.56, 1.84]
10.2 Serum sickness	1	371	Risk Ratio (M‐H, Random, 95% CI)	60.67 [3.74, 984.93]
10.3 Tremor	1	371	Risk Ratio (M‐H, Random, 95% CI)	0.93 [0.46, 1.87]
11 Serum creatinine	5		Mean Difference (IV, Random, 95% CI)	Subtotals only
11.1 At 6 months (+ CNI)	2	503	Mean Difference (IV, Random, 95% CI)	‐5.34 [‐13.44, 2.75]
11.2 At 1 year (+ CNI)	2	222	Mean Difference (IV, Random, 95% CI)	‐10.56 [‐21.81, 0.69]
11.3 At 1 year: LD recipients (no CNI)	1	30	Mean Difference (IV, Random, 95% CI)	‐9.70 [‐67.32, 47.92]
11.4 At 1 year: DD recipients (no CNI)	1	19	Mean Difference (IV, Random, 95% CI)	‐23.0 [‐62.70, 16.70]
11.5 At 5 years (+ CNI)	1	55	Mean Difference (IV, Random, 95% CI)	‐32.70 [‐68.98, 3.58]