Skip to main content
. 2012 Mar 14;2012(3):CD008449. doi: 10.1002/14651858.CD008449.pub2

Acerra 2007

Methods RCT
Participants Country: Australia
Sample size: 40 participants (20 in each group)
Inclusion criteria: acute stroke (< 2 weeks)
Exclusion criteria: previous stroke; vision or hearing impairment; acute trauma or impairment of the limbs; inability to sit for < 1 hour; MMSE < 22/30; major co‐morbidities
Interventions 2 arms:
  1. mirror therapy: participants were instructed to move both arms while looking in the mirror box, sensory stimulation

  2. sham therapy: patients performed the same treatment protocol as in group 1 but only viewing the unaffected arm


1 and 2: 5 days a week, 20 to 30 minutes for 2 weeks; additional usual rehabilitation programme
Outcomes Outcomes were recorded at baseline, after 2 weeks of treatment and 1 month after treatment
  • MAS (item 7 and 8, each 0 to 6)

  • Resting pain intensity (NRS 0 to 10); differential CRPS‐type 1 diagnosis

  • grip strength (handheld dynamometer)

  • sensory detection (synchiria yes/no, QST)

  • adverse events

Notes Unpublished data
We used means and SDs of Item 7 of the MAS, and combined the scores on pain intensity of shoulder and hand
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer generated random number sequence
Allocation concealment (selection bias) Low risk Generated list was used by an independent person for group allocation
ITT analysis Low risk Results were analysed on an ITT basis
Blinding of outcome assessment (detection bias) primary outcome Low risk Assessors were blinded to group allocation