Summary of findings 2. LC + LCBDE versus pre‐operative ERCP + LC for common bile duct stones.
| LC + LCBDE versuspre‐operative ERCP + LC for common bile duct stones | ||||||
| Patient or population: with common bile duct stones Settings: secondary or tertiary hospital Intervention: LC+ LCBDE | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Control | LC+ LCBDE | |||||
| Mortality at 30 days | Study population | OR 0.72 (0.12 to 4.33) | 580 (5 studies) | ⊕⊕⊕⊝ moderate1 | ||
| 10 per 1000 | 7 per 1000 (1 to 43) | |||||
| Moderate | ||||||
| 0 per 1000 | 0 per 1000 (0 to 0) | |||||
| Total morbidity | Study population | OR 1.28 (0.8 to 2.05) | 580 (5 studies) | ⊕⊕⊕⊝ moderate1 | ||
| 125 per 1000 | 155 per 1000 (103 to 227) | |||||
| Moderate | ||||||
| 125 per 1000 | 155 per 1000 (103 to 227) | |||||
| Failure of procedure | Study population | OR 0.51 (0.16 to 1.59) | 580 (5 studies) | ⊕⊕⊕⊕ moderate1 | Random‐effects model | |
| 166 per 1000 | 92 per 1000 (31 to 241) | |||||
| Moderate | ||||||
| 169 per 1000 | 94 per 1000 (32 to 244) | |||||
| Retained stones after primary intervention | Study population | OR 0.79 (0.45 to 1.39) | 580 (5 studies) | ⊕⊕⊕⊕ moderate1 | ||
| 105 per 1000 | 85 per 1000 (50 to 140) | |||||
| Moderate | ||||||
| 125 per 1000 | 101 per 1000 (60 to 166) | |||||
| Conversion to open surgery | Study population | OR 1.46 (0.76 to 2.81) | 580 (5 studies) | ⊕⊕⊕⊕ moderate1 | ||
| 58 per 1000 | 82 per 1000 (44 to 147) | |||||
| Moderate | ||||||
| 59 per 1000 | 84 per 1000 (45 to 150) | |||||
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; OR: Odds ratio; | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1 Included low‐risk and high‐risk groups of surgical participants