Study	Reason for exclusion
Alten 2006	German summary of Kremer 2003 trial
FDA 2005	Review
Genant 2008	Long term extension of Kremer 2006
Genovese 2004	ACR meeting abstract. Full text of trial was published in 2005.
Genovese 2005a	ACR meeting abstract. RCT data provided in Genovese 2005; the rest is long‐term extension data
Genovese 2008b	Long‐term extension of Genovese 2005
Haggerty 2007	Long‐term extension of Kremer 2006
Hassett 2007	Based on only 20 patients from the ATTAIN RCT
Kremer 2008	Long‐term extension of Kremer 2006 trial
Kruger 2005	German summary of Kremer 2003 trial
Li 2008	Not an outcome of interest
NHS 2004	Not a RCT; a review of recent trials
Taylor 2006	Not a RCT; a review
Teng 2005	Not a RCT; a review
Weisman 2006	Outcome not of interest to systematic review
Wells 2008	Not a RCT

ACR = American College of Rheumatology 
 RCT = randomized controlled trial