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. 2014 Jan 23;2014(1):CD002840. doi: 10.1002/14651858.CD002840.pub3

Hornby 2012

Methods Method: RCT, cross‐over assignment
Method of randomisation: not described Blinding of outcome assessors: yes Adverse events: not described Deaths: not described Drop outs: not described ITT: not described
Participants Country: USA
30 people with chronic stroke
Ambulatory at study onset: not clearly described, probably yes
Inclusion criteria: unilateral supratentorial stroke; MMSE > 22; > 6 months stroke duration; < 0.9 m/s gait speed overground.
Exclusion criteria: lower extremity contracture; osteoporosis; cardiovascular/metabolic/respiratory instability; previous central/peripheral nerve injury; concurrent medications interacting with selective serotonin reuptake inhibitors (SSRIs)
Interventions 2 arms:
  1. CTL group will receive placebo drug alone or with BWSTT for 4 weeks

  2. EXP group will receive SSRIs alone or with BWSTT for 4 weeks

Outcomes Outcomes will be assessed at baseline and at the end of the intervention phase at 4 weeks:
Primary outcomes: peak treadmill speed
Secondary outcomes: overground walking speed
Other outcomes: gait kinematics, EMG activity
Notes