Comparison 5. PaO₂/FiO₂ (mm Hg): INO versus control.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 PaO2/FiO2 up to 24 hours	11	614	Mean Difference (IV, Random, 95% CI)	15.91 [8.25, 23.56]
1.1 High risk of bias trials	9	338	Mean Difference (IV, Random, 95% CI)	14.27 [8.23, 20.30]
1.2 Low risk of bias trials	2	276	Mean Difference (IV, Random, 95% CI)	14.94 [‐27.10, 56.98]
2 PaO2/FiO2 up to 48 hours	5	416	Mean Difference (IV, Random, 95% CI)	8.65 [‐2.80, 20.11]
3 PaO2/FiO2 up to 72 hours	5	450	Mean Difference (IV, Fixed, 95% CI)	6.88 [‐3.91, 17.68]
4 PaO2/FiO2 up to 96 hours	4	334	Mean Difference (IV, Fixed, 95% CI)	14.51 [3.64, 25.38]
5 PaO2/FiO2 difference from baseline up to 24 hours	3	155	Mean Difference (IV, Random, 95% CI)	42.90 [20.57, 65.23]