Markesbery 2002

Trial name or title	Prevention of Alzheimer's Disease by Vitamin E and Selenium
Methods
Participants	Healthy volunteers, 60 to 90 years of age excluding Alzheimer's dementia, or any other form of dementia, Huntington's disease, epilepsy, Parkinson's disease, brain tumour, multiple sclerosis, manic‐depressive disorder or schizophrenia; head injury with over 30 minutes' loss of consciousness within last 5 years; current alcohol or substance abuse; depression or anxiety disorder in the past 4 months or under treatment for depression or anxiety; using Aricept (donepezil), Cognex (tacrine), Exelon (rivastigmine), Reminyl (galantamine) or Hydergine (dihydroergotoxine); disabilities that may prevent completion of memory screen
Interventions	Vitamin E and selenium
Outcomes	Developing Alzheimer's disease, memory impairment
Starting date	May 2002 to 2003
Contact information	Cecil R. Runyons: 001 859 257 1412 Ext. 235; email: preadvise@1sv.uky.edu William Markesbery, Principle Investigator, Alzheimer's Disease Research Center, Sanders‐Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA. wmark0@email.uky.edu
Notes	Expected total enrolment 10,400. Same participants of the SELECT (Selenium and Vitamin E Cancer Prevention Trial) study looking at use of vitamin E and selenium for prevention of prostate cancer. Estimated completion August 2012. This trial is likely to be ineligible as participants are healthy controls