Study	Reason for exclusion
Alavi 2013	Not suitable placebo
Alavi 2014	Control group did not receive a suitable placebo.
Alzoubi 2012	Sample population did not have a diagnosis of MCI or AD.
Anand 2011	Sample population did not have a diagnosis of MCI or AD.
Anonymous 2014	Newsletter
Apostolova 2013	Not an RCT
Arlt 2012	Not an RCT
Biesalski 2010	Review
Bittner 2009	Retrospective design
Brewer 2010	Review
Carlsson 2002	Sample population did not have a diagnosis of MCI or AD.
Chan 2008‐2009	Used a nutriceutical formulation and there was no placebo.
Chan 2010	Used a nutriceutical formulation. Placebo was just inert ingredients.
Chapman 2014	Editorial
Clarke 2003	Vitamin E was used in conjunction with vitamin C. It examined the association of cognitive impairment with platelet activation and reactive oxygen species and total homocysteine levels.
Corbett 2014	Commentary
Cornelli 2010	Used a nutriceutical formulation, not vitamin E separately.
de Oliveira 2012	In vitro study
Dunham 2013	Review
Dysken 2009	No vitamin E intervention, just a questionnaire
Evans 2014	Editorial
Galasko 2012	Not suitable placebo
Geldmacher 2011	Pioglitazone was the primary intervention. Placebo was administered alongside vitamin E.
Gopalan 2014	Sample population did not have a diagnosis of MCI or AD.
Grodstein 2013	Sample population did not have a diagnosis of MCI or AD.
Guan 2012	No relevant outcome measures
Gutierrez 2009	Sample population did not have a diagnosis of MCI or AD.
Han 2011	Review
Hermann 2014	Newsletter
Jae 2006	Vitamin E intervention given to healthy older women.
Joshi 2012	Review
Jyvakorpi 2012	Not an RCT
Kamat 2008	Literature review about antioxidants
Kesse‐Guyot 2011a	Sample population did not have a diagnosis of MCI or AD.
Kesse‐Guyot 2011b	Sample population did not have a diagnosis of MCI or AD.
Kryscio 2013a	Sample population did not have a diagnosis of MCI or AD.
Kryscio 2013b	Sample population did not have a diagnosis of MCI or AD.
Lee 2010	Literature review about antioxidants
Lehtisalo 2013	No vitamin E intervention group
Lehtisalo 2014	No vitamin E intervention group
Lewis 2014	Sample population did not have a diagnosis of MCI or AD.
Li 2015	No placebo group
Lott 2011	Sample population had a diagnosis of Down's syndrome and dementia.
Lu 2009	Focus of intervention was towards depressed vs non‐depressed MCI population.
MacPherson 2012	Sample population did not have a diagnosis of MCI or AD.
Mecocci 2012	Review
Mishra 2012	Survey
Morris 2012a	Review
Morris 2012b	Review
Muss 2015	Sample population did not have a diagnosis of MCI or AD.
Naeini 2014	No co‐administration of other compounds to controls
Onofrj 2002	Vitamin E compared to donepezil not placebo.
Pavlik 2009	Retrospective in nature. No controls or placebo group
Podea 2012	Not an RCT
Polidori 2012	Review
Pribis 2012	Did not use vitamin E as an intervention.
Péneau 2011	Not a randomised double‐blinded study; investigated the intake of fruits and vegetables.
Remington 2009	Used a nutriceutical formulation and the placebo was inert.
Remington 2015	Used a nutriceutical formulation.
Rijpma 2014a	Systematic review
Rijpma 2014b	Used a nutriceutical formulation.
Satalich 2014	Secondary analysis (modelling) of intervention data
Schmitt 2009	Used a healthy population.
Schneider 2009	Same data as Petersen 2005
Shea 2013	Used a nutriceutical formulation, not vitamin E separately.
Srour 2013	Vitamin C taken by treatment arm but not controls, no relevant outcomes.
Stough 2012	Sample population did not have a diagnosis of MCI or AD.
Suominen 2013	Vitamin E not administered
Takahashi 2009	Case study, no placebo and no controls
Usoro 2010	Review
Vinyoles‐Bargallo 2010	Not an original paper, just a personal comment
von Arnim 2013	Vitamin E not administered
Whitehair 2010	Same data as Petersen 2005
Zanotta 2014	Not an RCT

AD: Alzheimer's dementia; MCI: mild cognitive impairment; RCT: randomised controlled trial.