Comparison 3.

Cognitive test scores

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 ADAS‐Cog (original) at 6 months	2	562	Mean Difference (IV, Random, 95% CI)	0.86 [‐1.77, 3.48]
2 ADAS‐Cog (modified) at 1 year	4	3170	Mean Difference (IV, Random, 95% CI)	‐0.65 [‐1.30, ‐0.01]
3 ADAS‐Cog (modified) at 2 years	4	2675	Mean Difference (IV, Random, 95% CI)	‐0.78 [‐1.92, 0.35]
4 CDR sum of boxes at 1 year	2	1269	Mean Difference (IV, Random, 95% CI)	‐0.10 [‐0.11, ‐0.09]
5 Symbol Digit Modalities Test at 6 months	2	312	Mean Difference (IV, Random, 95% CI)	0.17 [‐2.87, 3.21]
6 MMSE at 1 year	2	1269	Mean Difference (IV, Random, 95% CI)	0.24 [‐0.13, 0.61]
7 ADCS‐ADL at 6 months	2	562	Mean Difference (IV, Random, 95% CI)	‐0.55 [‐3.35, 2.24]
8 ADCS‐ADL at 1 year	3	2408	Mean Difference (IV, Random, 95% CI)	0.15 [‐0.27, 0.57]