. 2016 Nov 17;2016(11):CD006667. doi: 10.1002/14651858.CD006667.pub3

2. Outcomes considered for this review.

Study	Mortality	Oxygenation	Adverse events
Cavalcanti et al, 2013	N/A	PaO₂/FiO₂	Barotrauma
Hodgson 2011	1. in hospital	PaO₂/FiO₂	Barotrauma Rescue therapies
Huh 2009	1. 28‐day 2. in ICU	PaO₂/FiO₂	Barotrauma Rescue therapies
Kacmarek 2016	1. in hospital 2. in ICU		Barotrauma
Liu 2011	28‐day	PaO₂/FiO₂	Barotrauma
Meade 2008	28‐day in hospital in ICU during mechanical ventilation	PaO₂/FiO₂	Barotrauma Rescue therapies
Oczenski 2004	N/A	PaO₂/FiO₂	N/A
Wang 2009	N/A	PaO₂/FiO₂	N/A
Xi 2010	28‐day in hospital in ICU	PaO₂/FiO₂	Barotrauma
Yang 2011	N/A	SpO₂ PaO₂/FiO₂	Barotrauma Pneumonia

CO = cardiac output; FiO₂/PEEP step = changes in level of inspired oxygen at set levels of positive end‐expiratory pressure; HR = heart rate; ICU = intensive care unit; MAP = mean arterial pressure; N/A = not available; PaO₂/FiO₂ = fraction of arterial oxygen to inspired oxygen; SBP = systolic blood pressure; SpO₂ = oxygen saturation from pulse oximetry.