Huh 2009.
Methods | Prospective, single‐centre, parallel‐group RCT | |
Participants | n = 57. Inclusion criteria: ARDS, PaO2/FiO2 < 200 in Korea and Seoul | |
Interventions | Treatment: extended sigh method of recruitment manoeuvre to peak of 55 cm H2O airway pressure and VCV with VT decreased by 25% from baseline, performed daily for 7 days. PCV, VT = 6 mL/kg, optimal PEEP setting determined during decremental PEEP titration. RM was also performed after oxygen desaturation or circuit disconnection. Control: ARDSNet protocol, with table‐based FiO2/PEEP strategy, PCV, VT = 6 mL/kg |
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Outcomes | Primary: oxygenation measured with PaO2/FiO2 daily for 7 days Secondary: PEEP and dynamic compliance (daily for 7 days), ICU LOS, duration of sedatives and paralysing agents, duration of MV, 28‐day mortality, 60‐day mortality and 90‐day mortality |
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Notes | Exclusion criteria not clearly stated, but 4 participants with fulminant hepatitis or terminal cancer were excluded. Contacted study author directly by email for additional details and received a response on 19.03.2015 | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Use of a randomization scheme |
Allocation concealment (selection bias) | Unclear risk | Not stated |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Not stated |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Participant follow‐up was incomplete. |
Selective reporting (reporting bias) | Unclear risk | 4 participants who withdrew from the study were excluded from the analysis. It is unclear on what bases these participants were excluded. |
Intention to treat | High risk | 4 participants who withdrew from the study were excluded from the analysis. It is unclear on what bases these participants were excluded. |