Yozbatiran 2006

Methods	Controlled clinical trial with alternate allocation
Participants	Country: Turkey Setting: acute inpatient medical care at a univeristy hospital 36 stroke patients (18 intervention group, 18 control group) Age: intervention group mean 69.5 years (SD 14), control group mean 66.7 years (SD 11.2) Intervention group: 15 females 3 males; control group 6 females 12 males Days since stroke: 9.5 days (SD 3.6) intervention group; 9.8 days (SD 5.9) control group Inclusion criteria: first stroke, in an acute inpatient setting Exclusion criteria: potentially fatal heart arrhythmias, prior stroke with residual motor deficits, lower motor neuron lesion of the impaired extremity, uncontrolled hypertension, significant orthopedic or chronic pain conditions
Interventions	Control group: 1 hour per day of neurodevelopment exercise for 10 days Intervention group: 1 hour per day of neurodevelopment exercise for 10 days plus received additional electrical stimulation of wrist and finger extensors for 1 hour per day
Outcomes	Outcome measures: recorded at baseline and post intervention Kinesthesia Position sense Hand function test Hand movement scale
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation?	High risk	Quote: "Controlled Clinical trial with alternate allocation" Quote: "Thirty six acute stroke subjects were assigned in ranked order"
Allocation concealment?	High risk	Alternate allocation was not concealed
Blinding? All outcomes	High risk	Quote "The following parameters were recorded at initial assessment and at discharge by the same experienced physiotherapist working with neurological patients" No indication of blinding
Incomplete outcome data addressed? All outcomes	Low risk	Quote: "There were no drop outs in the study"
Free of selective reporting?	Low risk	It is clear that the published reports include all of the study's pre‐specified outcomes
Free of other bias?	Low risk	The study appears to be free of other sources of bias; some differences at baseline but these were in favor of the control group