Date	Event	Description
13 October 2010	New citation required and conclusions have changed	This review suggests that no clear indications are known for iNO in preterm infants. Previous versions of this review suggested that early routine treatment might be beneficial, but with addition of the EUNO 2009 results, reduction in death or BPD and reduction in brain injury, which appeared possible previously, are no longer significant.
13 October 2010	New search has been performed	This updates the review, "Inhaled nitric oxide for respiratory failure in preterm infants", which was published in the Cochrane Database of Systematic Reviews (Barrington 2006). The search was updated in June 2010. Three new trials have been added, along with follow‐up data from other studies.
28 October 2009	Amended	This review has been converted to new review format.
1 March 2007	New citation required but conclusions have not changed	Substantive amendments have been made.
1 March 2007	New search has been performed	This review is an update of the existing review, "Inhaled nitric oxide for respiratory failure in preterm infants" (Barrington 2006). This update includes additional information regarding completed trials by Ballard, Kinsella and Srisuparp. Overall analyses have been deleted, as study characteristics differ too much for these to be useful. Subgroup analyses are presented instead.