EUNO 2009.

Methods	Multi‐centre trial
Participants	800 infants between 24 weeks' and 28 weeks' gestation and 6 days enrolled at less than 24 hours of age. If intubated, they had to have received surfactant and could be enrolled if on CPAP requiring > 30% oxygen. Patients were ineligible if they required more than 50% O2 to maintain saturation over 85% on a mean airway pressure ≥ 8 cmH2O.
Interventions	Inhaled NO at 5 ppm for at least 7 and a maximum of 21 days
Outcomes	Primary outcome was survival without BPD at 36 weeks' postmenstrual age. Secondary outcome was survival without severe brain injury on head ultrasonography.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer generated
Allocation concealment (selection bias)	Low risk	Centralised interactive Web‐based enrolment and randomisation system
Blinding (performance bias and detection bias) All outcomes	Low risk	Masking of intervention: yes Masking of outcome assessment: yes
Incomplete outcome data (attrition bias) All outcomes	Low risk	Completeness of follow‐up: yes
Selective reporting (reporting bias)	Low risk	Registered trial, primary outcomes reported
Other bias	Low risk
Funding Source	High risk	Funded by industry (Ikaria), initiated by investigators