| Methods |
Single‐centre trial |
| Participants |
34 infants weighing < 2000 grams, ventilated after surfactant with an arterial catheter at < 72 hours of age. Also required to satisfy a severity of illness criterion. OI > 4 for birth weight < 1000 grams, > 6 for birth weight 1001‐1250 grams, > 8 for 1251‐1500 grams, > 10 for 1501‐1750 grams and > 12 for 1751‐2000 grams |
| Interventions |
iNO at 20 ppm or standard care, trial of weaning after 72 hours, maximum duration 7 days |
| Outcomes |
Primary outcome was severe intraventricular haemorrhage (grade 3 or 4). |
| Notes |
Performed as a preliminary pilot study, before Schreiber 2003
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
No details available |
| Allocation concealment (selection bias) |
Unclear risk |
Masking of allocation: unclear |
| Blinding (performance bias and detection bias)
All outcomes |
High risk |
Unmasked trial |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
Completeness of follow‐up: yes |
| Selective reporting (reporting bias) |
Unclear risk |
No registration or protocol found |
| Funding Source |
Unclear risk |
Not stated |
