Yoder 2013.

Methods	Multi‐centre parallel‐group randomised trial
Participants	451 preterm infants, < 1250 grams and < 30 weeks, at 5 to 14 days of age, on invasive ventilation, or on non‐invasive support if they weighed < 800 grams
Interventions	iNO at 20 ppm for 3 to 4 days, then 10 ppm for 10 days, then 5 ppm until 24 days
Outcomes	Survival without BPD, duration of respiratory support and hospitalisation
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Centralised computer‐generated
Allocation concealment (selection bias)	Low risk	Placebo‐controlled trial
Blinding (performance bias and detection bias) All outcomes	Low risk	Masked trial
Incomplete outcome data (attrition bias) All outcomes	Low risk	No significant attrition
Selective reporting (reporting bias)	Low risk	Registered trial, primary outcomes reported
Other bias	Low risk
Funding Source	High risk	Industry initiated and funded (Ikaria)

a/AO2: arterial‐alveolar oxygen ratio.
 BPD: bronchopulmonary dysplasia.
 CMV: cytomegalovirus.
 CPAP: continuous positive airway pressure.
 FiO2: fraction of inspired oxygen.
 HVOF: high‐velocity oxygen fuel.
 iNO: inhaled nitric oxide.
 IVH: intraventricular haemorrhage.
 MRC: Medical Research Council.
 NEC: necrotising enterocolitis.
 NICHD: Eunice Kennedy Shriver National Institute of Child Health and Human Development.
 NO: nitric oxide.
 PDA: patent ductus arteriosus.
 PVL: periventricular leukomalacia.
 RDS: respiratory distress syndrome.
 ROP: retinopathy of prematurity.