Holmes 2002.

Methods
Participants
Interventions
Outcomes
Notes	See Table 1
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	“The communal area of the unit was diffused [...], on alternate days [...].”
Allocation concealment (selection bias)	High risk	Not described‐ although CCT design means the sequence was predictable.
Blinding (performance bias and detection bias) Subjective outcomes	Low risk	Agitation measured by "an experienced independent blinded (using nose callipers prior to entry onto the ward) rater, unaware of the study design"
Blinding (performance bias and detection bias) Objective outcomes	Unclear risk	The study did not address this outcome.
Incomplete outcome data (attrition bias) All outcomes	Low risk	"Fifteen patients were recruited [...]. For each subject 10 total PAS scores were obtained." Results were obtained from all the patients that were recruited and therefore it is indicated that there were no dropouts or withdrawals.
Selective reporting (reporting bias)	Unclear risk	Not known.
Protection from contamination?	High risk	Cross‐over trial.