3. Sensitivity analysis to explore heterogeneity for VT‐IPD, ITT (Random).

Study	log RR	SE	Weight	Point estimate RR (95% CI)	Reasons for exclusion
					Outlier	Small number of events
Eskola 2001	‐1.7904	1.6323	4.70%	0.17 [0.01, 4.09]
Kilpi 2003	‐1.7952	1.6311	4.70%	0.17 [0.01, 4.06]
Lucero 2009	1.0953	1.1545	8.50%	2.99 [0.31, 28.73]
Klugman 2003	‐1.772	0.7684	15.50%	0.17 [0.04, 0.77]
O'Brien 2003	‐1.7487	0.7662	15.60%	0.17 [0.04, 0.78]
Black 2000	‐2.7969	0.6658	18.60%	0.06 [0.02, 0.22]
Cutts 2005	‐1.4159	0.3525	32.50%	0.24 [0.12, 0.48]
Total RR (95% CI)				0.20 [0.10, 0.42]	0.18 [0.11, 0.30]	0.17 [0.09, 0.31]
Note: Shaded cells represent excluded studies				Heterogeneity: Tau² = 0.30; Chi² = 9.07, df = 6 (P = 0.17); I² = 34%	Heterogeneity: Tau² = 0.00; Chi² = 3.37, df = 5 (P = 0.64); I² = 0%	Heterogeneity: Tau² = 0.04; Chi² = 3.37, df = 3 (P = 0.34); I² = 11%
				Test for overall effect: Z = 4.31 (P < 0.0001)	Test for overall effect: Z = 6.58 (P < 0.00001)	Test for overall effect: Z = 5.90 (P < 0.00001)