6. Characteristics of studies with WHO X‐ray defined pneumonia.

Study	Age at enrolment	Follow up	Age at completion of primary series	Setting	No. of participants	PCV serotypes
Hansen 2006	2 months	Earliest of the following dates: onset of first invasive disease, death, end of trial	12 months	Northern California Kaiser Permanente (NCKP)	37,868	4, 6B, 9V, 14, 18C, 19F, 23F
Cutts 2005	6‐51 weeks	Earliest of the following dates: first episode of the relevant endpoint, withdrawal, death, age 30 months, end of follow‐up on April 30, 2004	6 months	The Gambia	17,437	1, 4, 5, 6B, 9V, 14, 18C, 19F, 23F
Klugman 2003 (HIV‐1 negative children only)	28‐84 days	60‐1354 days after enrolment	9 months	Soweto, South Africa	37,259	1, 4, 5, 6B, 9V, 14, 18C, 19F, 23F
Lucero 2009	6 weeks‐ < 6 months	Earliest of the following dates: 24 months of age, end of follow‐up on December 31, 2004	6 months	Philippines	12,191	1, 3, 4, 5, 6B, 7F, 9V, 14, 18C, 19F, 23F
O'Brien 2002	6 weeks‐7 months of age	First 24 months of life	12 months	American Indian and Apache Indian Reservations	5792	4, 6B, 9V, 14, 18C, 19F, 23F