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. 2016 Mar 21;2016(3):CD009645. doi: 10.1002/14651858.CD009645.pub3

Kim 2009.

Methods Study design: single‐blinded, sham‐controlled, randomised cross‐over study
Dropouts: none
Adverse effects: none
Deaths: none
ITT: yes
Participants Country: Republic of Korea
Number of participants: 10 subacute participants
Age: (mean) 62.8 years
Gender: seven female (70%)
Type of stroke: first‐ever stroke, as confirmed by MRI; 2 had haemorrhagic stroke (20%)
Time poststroke: (mean) 6.4 weeks, range 3 to 12 weeks
Severity: participants could grasp and release independently; degree of strength according to MRC was ≥ 3 but < 5 for all paretic finger flexors and extensors. Participants did not have a family history of seizure, could understand the purpose of the study and did not have any deformities or contractures of the fingers, hands, elbows and shoulders
Inclusion criteria: not explicitly stated
Exclusion criteria: not explicitly stated
Interventions Each participant underwent 2 different stimulation conditions, each for 20 minutes, separated by at least 24 hours of rest
  1. A‐tDCS (1 mA) over the primary motor cortex of the first dorsal interossei muscle of the lesioned hemisphere

  2. Sham tDCS over the primary motor cortex of the first dorsal interossei muscle of the lesioned hemisphere

Outcomes
  1. Box and Block test (the transfer of as many wooden blocks as possible with the lesioned hand from 1 compartment to the other within 1 minute, with a high value indicating good function) and finger acceleration measurement (in g, with a higher value indicating higher acceleration) at baseline, at 5 minutes of stimulation, immediately and at 30 and 60 minutes after stimulation

  2. Visual analogue scales to assess attention and fatigue (score 1 to 7; 1 = no attention/fatigue; 7 = highest level of attention/fatigue) at baseline, immediately and at 30 and 60 minutes after stimulation

Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "A doctor who works in tDCS's room, he randomised patients on his own sequence" (Kim 2013 [pers comm])
Allocation concealment (selection bias) Unclear risk Quote: "A doctor who works in tDCS's room, he randomised patients on his own sequence" (Kim 2013 [pers comm])
Blinding of participants and personnel (performance bias) 
 Subjective outcome measures Low risk Both participants and personnel were blinded (Kim 2013 [pers comm])
Blinding of participants and personnel (performance bias) 
 Objective outcome measures Low risk Both participants and personnel were blinded (Kim 2013 [pers comm])
Blinding of outcome assessment (detection bias) 
 Subjective outcome measures High risk No blinding of outcome assessors. Quote: "An examiner who was aware of the stimulation method used was instructed not to communicate with patients during the task and evaluated patients’ performances"
Blinding of outcome assessment (detection bias) 
 Objective outcome measures Low risk No blinding of outcome assessment, but the review authors judge that the outcome measurement is not likely to be influenced by lack of blinding. Quote . Quote: "An examiner who was aware of the stimulation method used was instructed not to communicate with patients during the task and evaluated patients’ performances"
Incomplete outcome data (attrition bias) 
 Subjective outcome measures Low risk All randomised participants apparently completed the study. No treatment withdrawals, no losses to follow‐up, no trial group changes and no major adverse events were stated
Incomplete outcome data (attrition bias) 
 Objective outcome measures Low risk All randomised participants apparently completed the study. No treatment withdrawals, no losses to follow‐up, no trial group changes and no major adverse events were stated
Selective reporting (reporting bias) Unclear risk All outcomes reported in the methods section reported