NCT02166619.

Trial name or title	Transcranial direct current stimulation in rehabilitation of chronic stroke patients: multicenter clinical trial
Methods	Randomised controlled trial with parallel‐group design
Participants	Estimated enrolment: 24 Inclusion criteria: age between 40 and 80 years; primary or recurrent stroke, confirmed by CT or MRI; stroke > 12 months prior to enrolment; upper limb impairment due to stroke; MMSE ≥ 18; Ashworth Scale ≥ 4; minimal active wrist movement (flexion and extension); at least one pinch movement Exclusion criteria: prior neurological diseases; multiple brain lesions; metal implant in the head; pacemaker; history of seizures; epilepsy; pregnancy; haemodynamic instability; cointervention of physical therapy elsewhere during the study; initial UE‐FM > 59; traumatic or orthopaedic lesion limiting the range of motion of the upper limb
Interventions	2 arms Dual‐tDCS with the anode over the affected hemisphere and the cathode over the unaffected hemisphere (2 mA for 20 minutes) followed by 40 minutes of physical therapy 5 times per week for 2 weeks Sham tDCS with the anode over the affected hemisphere and the cathode over the unaffected hemisphere (2 mA for 20 minutes) followed by 40 minutes of physical therapy 5 times per week for 2 weeks
Outcomes	Outcomes will be recorded at baseline and at days 30 and 90 Primary outcome measure: Change in UE‐FM Secondary outcome measures: Change in MAL‐30 Other outcome measures: Change in JTT
Starting date	December 2013
Contact information	Kátia Monte‐Silva, PhD Déborah Marques, PT Applied Neuroscience Laboratory, Universidade Federal de Pernambuco Recife, PE, Brazil, 50670‐900
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