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. 2016 Mar 21;2016(3):CD009645. doi: 10.1002/14651858.CD009645.pub3

NCT02399540.

Trial name or title Late LTP‐like plasticity effects of tDCS in chronic stroke patients
Methods RCT with parallel‐group design
Participants Estimated enrolment: 80
Inclusion criteria: aged 18 to 79 years; stroke onset > 6 months prior to enrolment; motor deficit in the upper limb due to the stroke
Exclusion criteria: absence of MEPs; absence of voluntarily movement (Fugl‐Meyer Stage < III); head injury or metal in the head; history of cranial irradiation; history of epilepsy; pacemaker; anticonvulsant or neuroleptic medication; substance abuse; inability to understand instructions; history of psychiatric disorders
Interventions 4 arms
  1. Day 1: sham tDCS; Day 2: sham tDCS

  2. Day 1: sham tDCS; Day 2: conventional paired tDCS

  3. Day 1: conventional unpaired tDCS; Day 2: sham tDCS

  4. Day 1: late LTP‐like plasticity tDCS; Day 2: sham tDCS

Outcomes Primary outcome measures
  1. Motor skill retention (at day 9)


Secondary outcome measures
  1. Maximum grip force (at day 1 and at day 9)

  2. PPT (at day 1 and at day 9)

Starting date March 2015
Contact information Contact: Rick van der Vliet, MSc
Rijndam
Rotterdam, Zuid‐Holland, Netherlands, 3015LJ
Notes