NCT02416791.

Trial name or title	Robotic therapy and transcranial direct current stimulation in patients with stroke
Methods	RCT with parallel‐group design
Participants	Estimated enrolment: 51 Inclusion criteria: stroke onset 3 to 9 weeks prior to enrolment, radiologically confirmed; UE‐FM between 7 and 38; ability to provide informed consent; ability to comply with the schedule of interventions and evaluation of the protocol Exclusion criteria: MAS > 3 in the paretic arm; upper limb plegia; uncontrolled medical conditions; pregnancy; seizures; pacemakers; other neurological disorders; psychiatric illnesses; aphasia compromising comprehension of the experimental protocol; MMSE < 23 for patients with > 1 year of education and MMSE < 19 for patients with > 1 year of education; hemineglect
Interventions	2 arms C‐tDCS over M1 of the affected hemisphere (1 mA for 20 minutes) prior to robotic training with the MIT‐Manus, followed by physical therapy for 40 minutes 3 times a week for 6 weeks Sham tDCS over M1 of the affected hemisphere prior to robotic training with the MIT‐Manus, followed by physical therapy for 40 minutes 3 times a week for 6 weeks Sham tDCS over M1 of the affected hemisphere prior to physical therapy for 40 minutes, followed by occupational therapy for 40 minutes 3 times a week for 6 weeks
Outcomes	Primary outcome measures Change in UE‐FM (at 6 weeks) Adverse events (at 6 weeks) Secondary outcome measures mRS (change from baseline to 6 weeks) NIHSS (change from baseline to 6 weeks) SIS (change from baseline to 6 weeks) MAS (change from baseline to 6 weeks) MAL (change from baseline to 6 weeks) UE‐FM (at 6 months) Adverse events (at 6 months) FSS (change from baseline to 6 weeks) Pittsburgh Sleep Quality Index (change from baseline to 6 weeks)
Starting date	June 2015
Contact information	Thais Midori K Tokuno Hospital das Clínicas São Paulo, SP, Brazil, 05403900
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