NTR3315.

Trial name or title	The effect of noninvasive brain stimulation on lower limb motor skill acquisition
Methods	Randomised controlled double‐blind trial with parallel assignment
Participants	60 participants 18 years of age or older with hemiparesis due to a first‐time ever ischaemic subcortical stroke at least 6 months before study enrolment, good vision on 2 metre distance, being able to stand and to make stepping movements for 42 minutes, independent walkers with clear walking impairment Exclusion criteria: metallic implants in the brain, presence of severe or frequent headache, other neurological disorders or orthopaedic problems, history of cardiac conditions that interfere with physical load
Interventions	3 training sessions with 3 different interventions of tDCS during the first 10 minutes of each training session Experimental 1: A‐tDCS of M1 Experimental 2: A‐tDCS of cerebellum Sham comparator: Sham tDCS
Outcomes	Primary outcome measure Relative change in motor skill between the first and last training blocks (total learning) Secondary outcome measure Change in motor skill during motor skill training (online learning) Change in motor skill between 2 consecutive motor skill training sessions (offline learning)
Starting date	1 March 2012
Contact information	Edwin van Asseldonk, e.h.f.vanasseldonk@utwente.nl
Notes