3. Mean or median haemoglobin (Hb) levels and HbS percentage.
| Trial | Intervention | Baseline | 6 to 12 months | 12 to 18 months | 18 to 24 months | ||||
| Hb (g/L) | Hb S (%) | Hb (g/L) | Hb S (%) | Hb (g/L) | Hb S (%) | Hb (g/L) | Hb S (%) | ||
| No previous long‐term transfusions | |||||||||
| SIT 2014 | Transfusion | Median 77 IQR (72 to 84) |
Median 85 90% CI (51 to 95) |
‐ | Median 30 90% CI (17 to 43) |
‐ | Median 29 90% CI (16 to 43) |
‐ | Median 30 90% CI (16 to 43) |
| Standard | Median 79 IQR (74 to 89) |
‐ | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | |
| STOP 1998 | Transfusion | Mean (SD) 72 (8) | Mean (SD) 87 (10) | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ |
| Standard | Mean (SD) 76 (7) | Mean (SD) 87 (7) | ‐ | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Previous long‐term transfusions | |||||||||
| STOP 2 2005 | Transfusion | Mean (SD) 93 (9) |
Mean (SD) 21 (8.6) |
Mean (SD) 94 (9) |
Mean (SD) 25.4 (10.9) |
‐ | ‐ | ‐ | ‐ |
| Standard | Mean (SD) 98 (12) |
Mean (SD) 19 (11) |
Mean (SD) 77 (8) |
Mean (SD) 81.0 (8.6) |
‐ | ‐ | ‐ | ‐ | |
Abbreviations: CI: confidence interval; IQR: interquartile range; SD: standard deviation