Branchi 2002.

Methods	Wash‐out period was not required because no participants were taking drugs known to affect lipid metabolism 2‐Month treatment period
Participants	121 men and women outpatients from Italy with diet‐resistant hypercholesterolaemia, mean age 57 years (24‐77) Exclusion criteria: diabetes, hypothyroidism, renal failure, liver disease Baseline TC: 8.1 mmol/L (313 mg/dL) Baseline LDL‐C: 5.73 mmol/L (222 mg/dL) Baseline HDL‐C: 1.31 mmol/L (50.7 mg/dL) Baseline TG: 2.33 mmol/L (206 mg/dL)
Interventions	Atorvastatin 10 mg/d
Outcomes	Per cent change from baseline at 1 month of serum TC, LDL‐C, HDL‐C and TG
Notes	SDs were imputed
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Atorvastatin 10 mg/d; intervention was analysed, and as no placebo group was included for comparison, assessment of random sequence generation is not applicable
Allocation concealment (selection bias)	Unclear risk	Atorvastatin 10 mg/d; intervention was analysed, and as no placebo group was included for comparison, assessment of allocation concealment is not applicable
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Atorvastatin 10 mg/d; intervention was analysed, and as no placebo group was included for comparison, blinding status is not applicable
Incomplete outcome data (attrition bias) All outcomes	Low risk	Data on all participants were reported
Selective reporting (reporting bias)	Low risk	All lipid parameters were measured
Other bias	Unclear risk	The source of funding was not reported