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. 2015 Mar 11;2015(3):CD008226. doi: 10.1002/14651858.CD008226.pub3

Kural 2004.

Methods No participants had been receiving lipid‐lowering drug treatment; therefore no wash‐out period was required
6‐Week to 12‐week before‐and‐after trial
Participants 40 men and women from Turkey with dyslipidaemia aged 53 years (41‐65)
Exclusion criteria: hypothyroidism, diabetes mellitus, nephrotic syndrome, renal insufficiency, hepatic dysfunction, cancer, immune disorder, uncontrolled HTN, smoking, CAD
Baseline TC: 7.45 mmol/L (288 mg/dL)
 Baseline LDL‐C: 5.28 mmol/L (204 mg/dL)
 Baseline HDL‐C: 1.06 mmol/L (41 mg/dL)
 Baseline TG: 2.27 mmol/L (201 mg/dL)
Interventions Atorvastatin 40 mg/d
Outcomes Per cent change from baseline at 4 weeks of serum TC, LDL‐C, HDL‐C and TG
Notes SDs were imputed
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Atorvastatin 40 mg/d; intervention was analysed, and as no placebo group was included for comparison, assessment of random sequence generation is not applicable
Allocation concealment (selection bias) Unclear risk Atorvastatin 40 mg/d; intervention was analysed, and as no placebo group was included for comparison, assessment of allocation concealment is not applicable
Blinding (performance bias and detection bias) 
 All outcomes Unclear risk Atorvastatin 40 mg/d; intervention was analysed, and as no placebo group was included for comparison, blinding status is not applicable
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Data on all participants were reported
Selective reporting (reporting bias) Low risk All lipid parameters were measured
Other bias Low risk The study appears to be free of other sources of bias