Kural 2004.
Methods | No participants had been receiving lipid‐lowering drug treatment; therefore no wash‐out period was required 6‐Week to 12‐week before‐and‐after trial |
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Participants | 40 men and women from Turkey with dyslipidaemia aged 53 years (41‐65) Exclusion criteria: hypothyroidism, diabetes mellitus, nephrotic syndrome, renal insufficiency, hepatic dysfunction, cancer, immune disorder, uncontrolled HTN, smoking, CAD Baseline TC: 7.45 mmol/L (288 mg/dL) Baseline LDL‐C: 5.28 mmol/L (204 mg/dL) Baseline HDL‐C: 1.06 mmol/L (41 mg/dL) Baseline TG: 2.27 mmol/L (201 mg/dL) |
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Interventions | Atorvastatin 40 mg/d | |
Outcomes | Per cent change from baseline at 4 weeks of serum TC, LDL‐C, HDL‐C and TG | |
Notes | SDs were imputed | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Atorvastatin 40 mg/d; intervention was analysed, and as no placebo group was included for comparison, assessment of random sequence generation is not applicable |
Allocation concealment (selection bias) | Unclear risk | Atorvastatin 40 mg/d; intervention was analysed, and as no placebo group was included for comparison, assessment of allocation concealment is not applicable |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Atorvastatin 40 mg/d; intervention was analysed, and as no placebo group was included for comparison, blinding status is not applicable |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Data on all participants were reported |
Selective reporting (reporting bias) | Low risk | All lipid parameters were measured |
Other bias | Low risk | The study appears to be free of other sources of bias |