Li 2010.
Methods | Participants were not receiving lipid‐altering agents, so no wash‐out was required 12‐Week before‐and‐after trial |
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Participants | 84 men and women with CHD aged 55 to 76 years Exclusion criteria: liver or renal failure, diabetes mellitus, MI, HTN, severe or unstable angina pectoris, heart failure, severe cardiac arrhythmia, transplantation Atorvastatin 10 mg/d baseline TC: 5.43 mmol/L (210 mg/dL) Atorvastatin 10 mg/d baseline LDL‐C: 3.31 mmol/L (128 mg/dL) Atorvastatin 10 mg/d baseline HDL‐C: 1.13 mmol/L (44 mg/dL) Atorvastatin 10 mg/d baseline TG: 1.68 mmol/L (149 mg/dL) |
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Interventions | Atorvastatin 10 mg/d Simvastatin 20 mg/d |
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Outcomes | Per cent change from baseline at 12 weeks of serum TC, LDL‐C, HDL‐C and TG | |
Notes | Atorvastatin group was analysed | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Atorvastatin 10 mg/d; intervention was analysed, and as no placebo group was included for comparison, assessment of random sequence generation is not applicable |
Allocation concealment (selection bias) | Unclear risk | Atorvastatin 10 mg/d; intervention was analysed, and as no placebo group was included for comparison, assessment of allocation concealment is not applicable |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Atorvastatin 10 mg/d; intervention was analysed, and as no placebo group was included for comparison, blinding status is not applicable |
Incomplete outcome data (attrition bias) All outcomes | Low risk | All participants were included in the efficacy analysis |
Selective reporting (reporting bias) | Low risk | All lipid parameters were measured |
Other bias | Low risk | The study appears to be free of other sources of bias |