Nordøy 2001.
Methods | 12‐Week to 16‐week wash‐out dietary stabilisation period 10‐Week before‐and‐after study |
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Participants | 42 men and women aged 28 to 61 years; TC ≥ 5.3 mmol/L (205 mg/dL), TG 2.0 to 15.0 mmol/L (177‐1329 mg/dL) Baseline TC: 7.99 mmol/L (309mg/dL) Baseline LDL‐C: 5.09 mmol/L (197 mg/dL) Baseline HDL‐C: 1.01 mmol/L (39 mg/dL) Baseline TG: 4.02 mmol/L (356 mg/dL) |
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Interventions | All participants were given atorvastatin 10 mg/d for 5 weeks After 5 weeks, all participants were randomly assigned to 2 groups:
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Outcomes | Per cent change from baseline at 10 weeks of serum TC, LDL‐C, HDL‐C and TG | |
Notes | Both groups were analysed SDs were imputed |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Atorvastatin 10 mg/d; intervention was analysed, and as no placebo group was included for comparison, assessment of random sequence generation is not applicable |
Allocation concealment (selection bias) | Unclear risk | Atorvastatin 10 mg/d; intervention was analysed, and as no placebo group was included for comparison, assessment of allocation concealment is not applicable |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Atorvastatin 10 mg/d; intervention was analysed, and as no placebo group was included for comparison, blinding status is not applicable |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Data on all participants were reported |
Selective reporting (reporting bias) | Low risk | All lipid parameters were measured |
Other bias | Unclear risk | No source of funding was provided |