Puccetti 2005.

Methods	6‐Week dietary stabilisation period 6‐Week study
Participants	201 men and women with hypercholesterolaemia aged 37 to 61 years Exclusion criteria: history of cardiovascular events, HTN, diabetes; liver, renal, thyroid, infective, immunological or malignant disease Baseline TC: 6.57 mmol/L (254 mg/dL) Baseline LDL‐C: 4.84 mmol/L (187 mg/dL) Baseline HDL‐C: 1.22 mmol/L (47 mg/dL) Baseline TG: 1.10 mmol/L (97 mg/dL)
Interventions	Atorvastatin 20 mg/d
Outcomes	Per cent change from baseline at 6 weeks of serum TC, LDL‐C, HDL‐C and TG
Notes	SDs were imputed
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Atorvastatin 20 mg/d; intervention was analysed, and as no placebo group was included for comparison, assessment of random sequence generation is not applicable
Allocation concealment (selection bias)	Unclear risk	Atorvastatin 20 mg/d; intervention was analysed, and as no placebo group was included for comparison, assessment of allocation concealment is not applicable
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Atorvastatin 20 mg/d; intervention was analysed, and as no placebo group was included for comparison, blinding status is not applicable
Incomplete outcome data (attrition bias) All outcomes	Low risk	Data on all participants were reported
Selective reporting (reporting bias)	Low risk	All lipid parameters were measured
Other bias	Unclear risk	No source of funding was provided