Vadalà 2013.

Methods	Randomised controlled trial. Sequence generation and allocation methodology were not reported. Participants were followed for a mean of 14.7 months Trial conducted: no details available; recruitment: no details available
Participants	Participants: 40 undergoing ACL reconstruction Inclusion criteria: participants with chronic instability (> 30 days of trauma) Exclusion criteria: age > 50 years; concomitant medial or lateral collateral ligament injuries; degenerative joint disease or chondral damage (MRI or radiographic examinations) Age mean (range): 34.5 years (18‐48) PRT group mean (range): not available No PRT mean (range): not available Gender: all were men PRT group (number of men:women): 20:0 No PRT (number of men:women): 20:0 Sports activity: not available
Interventions	All patients underwent arthroscopic ACL reconstruction with hamstring graft PRT (number of participants = 20): single intraoperative application. PRP was applied in the femoral and tibial tunnel. 10 mL blood was centrifuged, thrombin and calcium gluconate added few minutes before its application in order to obtain a thick and adhesive gel PRT preparation: kit: PRP Fast Biotech kit (MyCells PPT‐Platelet Preparation Tube) Quantification of platelet concentrates after preparation: not reported No PRT (number of participants = 20): no platelet‐rich therapy controls Co‐interventions: same rehabilitation protocol
Outcomes	Tunnel enlargement (assessed by CT) Tegner activity score Lysholm score IKDC score
Other quality issues	Sample size: the authors did not calculate the sample size Validation of PRT: PRP preparation methodology was not clear and there are some inconsistencies between sections of the manuscript
Notes	The authors described different quantities for PRP preparation and application
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation	Unclear risk	Not reported
Allocation concealment	Unclear risk	Not reported
Blinding All outcomes	Low risk	Outcome assessors were blinded
Incomplete outcome data addressed All outcomes	Low risk	No participants were lost to follow‐up
Free of selective reporting	High risk	The study protocol is not available and the authors did not report outcomes at each time point
Free of other bias	Low risk	The study appears to be free of other bias