Vogrin 2010.

Methods	Quasi‐randomised controlled trial: sequence generated by the presence of odd or even numbers. Participants followed for 6 months after the procedure Trial conducted: Department of Orthopedic Surgery, University Hospital Maribor, Maribor, Slovenia; recruitment: February‐June 2008
Participants	Participants: 55 undergoing ACL reconstruction Inclusion criteria: participants with unstable knee resulting from ACL rupture; aged 18‐50 years Exclusion criteria: inflammatory diseases; diabetes mellitus; developed knee osteoarthrosis; malignant diseases; allergy to contrast media, renal diseases and thrombocytopenia Age: PRT group (mean ± SD): 35.4 years ± 10.0 No PRT (mean ± SD): 33.0 years ± 12.5 Gender: PRT group (number of men:women): 13:9 No PRT (number of men:women): 17:6 Sports activity: not available
Interventions	Arthroscopic ACL reconstruction with semitendinosus and gracilis tendons (fixed with 2 cross pins in the femur and 1 interference screw in the tibia) PRT (number of participants = 28): single, intraoperative application in the bone tunnels after graft placement. 52 mL blood mixed with 8 mL calcium citrate as anticoagulant. The authors pre‐defined the PRP volume as 6 mL, and the process resulted in 6 mL of PRP. The product was activated with human thrombin and applied in the surgical site PRT preparation: kit: Magellan autologous platelet separator (Medtronic Biologic Therapeutics and Diagnostics, Minneapolis, MN, USA) Quantification of platelet concentrates after preparation: 962 (552‐1326) g/L; participants' average blood platelet concentration:192 g/L No PRT (number of participants = 27): no platelet‐rich therapy controls Co‐interventions: same rehabilitation protocol
Outcomes	Knee stability (KT‐ 2000) Tegner activity score Lysholm score IKDC score
Other quality issues	Sample size: the authors did not calculate the sample size Validation of PRT: quantification reported
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Adequate sequence generation	High risk	Sequence generated by odd or even date ‐ quasi‐randomised
Allocation concealment	High risk	Quasi‐randomised clinical trial
Blinding All outcomes	High risk	The participants and outcome assessors were not blinded to the treatment
Incomplete outcome data addressed All outcomes	Low risk	Missing outcome data were balanced in numbers across intervention groups
Free of selective reporting	High risk	The study protocol is not available and the clinical follow‐up period was short for participants who underwent to ACL surgery
Free of other bias	Low risk	The study appears to be free of other bias