Comparison 8.

Varenicline in specific patient groups

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Cardiovascular disease	2	1006	Risk Ratio (M‐H, Fixed, 95% CI)	1.88 [1.44, 2.47]
2 COPD	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
3 Asthma	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
4 Schizophrenia/bipolar/psychiatric disorder	4	2332	Risk Ratio (M‐H, Fixed, 95% CI)	2.28 [1.82, 2.87]
5 Depression	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
6 Substance use disorder/methadone‐maintained at 24 weeks	2	294	Risk Ratio (M‐H, Fixed, 95% CI)	3.72 [0.50, 27.59]
7 Alcohol‐dependent smokers	1		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
8 Long‐term use of NRT	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected