Comparison 10.

Adverse event meta‐analyses

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Nausea	32	14963	Risk Ratio (M‐H, Fixed, 95% CI)	3.27 [3.00, 3.55]
2 Insomnia	29	14447	Risk Ratio (M‐H, Fixed, 95% CI)	1.49 [1.35, 1.65]
3 Abnormal dreams	26	13682	Risk Ratio (M‐H, Fixed, 95% CI)	2.12 [1.88, 2.38]
4 Headache	25	13835	Risk Ratio (M‐H, Fixed, 95% CI)	1.17 [1.07, 1.29]
5 Depression	36	16189	Risk Ratio (M‐H, Fixed, 95% CI)	0.94 [0.77, 1.14]
6 Suicidal ideation	24	11193	Risk Ratio (M‐H, Fixed, 95% CI)	0.68 [0.43, 1.07]