Comparison 13.

Sensitivity analysis

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 ITT treatment vs per protocol control	28	12422	Risk Ratio (M‐H, Fixed, 95% CI)	1.79 [1.65, 1.94]
2 Continuous abstinence at 9 ‐ 12 weeks	24	12339	Risk Ratio (M‐H, Fixed, 95% CI)	2.49 [2.33, 2.65]
3 Continuous abstinence at 24 weeks	26	14016	Risk Ratio (M‐H, Fixed, 95% CI)	2.44 [2.26, 2.63]