ACTRN12614000329662

Trial name or title	Examination of mechanism of action of pre‐quit use of nicotine patch and varenicline for smoking cessation [PQT]
Methods	Open‐label parallel‐group efficacy RCT
Participants	Up to 216 adults (18+), smoking 15+ CPD, high motivation to quit, willing and able to take either medication.
Interventions	(i) Varenicline, 2 wks before TQD and 4 wks after; or (ii) NRT 21 mg patch, starting 2 wks before TQD
Outcomes	Primary: 1. CPD reduction in 1st 2 wks 2. Measures of craving 3. Smoking satisfaction Secondary: 1. CO‐validated abstinence at 28 days post‐TQD
Starting date	March 2014
Contact information	PI and enquiries: stuart.ferguson@utas.edu.au
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