Source	Search strategy	Hits retrieved
1. ALOIS (www.medicine.ox.ac.uk/alois)	Keyword search: chinese OR plants OR huperzine OR HUP OR ayapin OR scoparon	92
2. MEDLINE In‐process and other non‐indexed citations and MEDLINE 1950 to present (Ovid SP)	1. mci.mp. 2. (cognit* adj3 impair*).mp. 3. AAMI.mp. 4. "age‐associated memory impairment".mp. 5. ("aMCI" or "MCIa").ti,ab. 6. AACD.mp. 7. "age‐associated cognitive decline".mp. 8. (CIND or SMC).mp. 9. (memor* adj3 complain*).mp. 10. ("pre‐clinical AD" or "preclinical AD" or "pre‐clinical Alzheimer*" or "preclinical Alzheimer*").mp. 11. (dement* adj2 prodrom*).mp. 12. "episod* memor*".mp. 13. dement*.mp. 14. Memory Disorders/ or Dementia/ or Cognition Disorders/ 15. or/1‐14 16. huperzi*.mp. 17. ayapin*.mp. 18. scoparon*.mp. 19. *Drugs, Chinese Herbal/ 20. *Medicine, East Asian Traditional/ 21. Plants, Medicinal/ 22. or/16‐21 23. randomized controlled trial.pt. 24. controlled clinical trial.pt. 25. randomi?ed.ab. 26. placebo.ab. 27. drug therapy.fs. 28. randomly.ab. 29. trial.ab. 30. or/23‐29 31. (animals not (humans and animals)).sh. 32. 30 not 31 33. 15 and 22 and 32	200
3. EMBASE 1980 to 2011 week 20 (Ovid SP)	1. mci.mp. 2. (cognit* adj3 impair*).mp. 3. AAMI.mp. 4. "age‐associated memory impairment".mp. 5. ("aMCI" or "MCIa").ti,ab. 6. AACD.mp. 7. "age‐associated cognitive decline".mp. 8. (CIND or SMC).mp. 9. (memor* adj3 complain*).mp. 10. ("pre‐clinical AD" or "preclinical AD" or "pre‐clinical Alzheimer*" or "preclinical Alzheimer*").mp. 11. (dement* adj2 prodrom*).mp. 12. "episod* memor*".mp. 13. dement*.mp. 14. *memory disorder/ 15. *dementia/ 16. *cognitive defect/ 17. or/1‐16 18. huperzi*.mp. 19. ayapin*.mp. 20. scoparon*.mp. 21. *Chinese medicine/ 22. *Chinese drug/ or *Chinese herb/ 23. huperzine A/ 24. or/18‐23 25. 17 and 24 26. randomized controlled trial/ 27. controlled clinical trial/ 28. randomi?ed.ab. 29. placebo.ab. 30. randomly.ab. 31. ("double‐blind*" or "double‐mask*" or "single‐blind*" or "single‐mask*").ti,ab. 32. trial.ti,ab. 33. or/26‐32 34. 25 and 33	111
4. PsycINFO 1806 to May week 3 2011 (Ovid SP)	1. mci.mp. 2. (cognit* adj3 impair*).mp. 3. AAMI.mp. 4. "age‐associated memory impairment".mp. 5. ("aMCI" or "MCIa").ti,ab. 6. AACD.mp. 7. "age‐associated cognitive decline".mp. 8. (CIND or SMC).mp. 9. (memor* adj3 complain*).mp. 10. ("pre‐clinical AD" or "preclinical AD" or "pre‐clinical Alzheimer*" or "preclinical Alzheimer*").mp. 11. (dement* adj2 prodrom*).mp. 12. "episod* memor*".mp. 13. dement*.mp. 14. *memory disorder/ 15. *dementia/ 16. huperzi*.mp. 17. ayapin*.mp. 18. scoparon*.mp. 19. exp *"Medicinal Herbs and Plants"/ 20. or/1‐15 21. or/16‐19 22. 20 and 21	140
5. CINAHL (EBSCOhost)	S1 TX "cognit* impair*"  S2 TX "cognit* defect*"  S3 (MH "Cognition Disorders+")  S4 TX MCI  S5 TX ACMI  S6 TX ARCD  S7 TX SMC  S8 TX CIND  S9 TX BSF  S10 TX AAMI  S11 AB MD  S12 AB LCD  S13 AB QD OR "questionable dementia" S14 TX AACD  S15 TX MNCD  S16 TX "N‐MCI" or "A‐MCI" or "M‐MCI" S17 TX "preclinical AD"  S18 TX "pre‐clinical AD" S19 TX "preclinical alzheimer*" or "pre‐clinical alzheimer*"  S20 TX aMCI OR MCIa  S21 TX "CDR 0.5" or "clinical dementia rating scale 0.5"  S22 TX "GDS 3" OR "stage 3 GDS" S23 TX "global deterioration scale" AND "stage 3"  S24 TX "Benign senescent forgetfulness"  S25 TX "mild neurocognit* disorder*"  S26 TX prodrom* N2 dement* S27 TX "age‐related symptom*"  S28 TX cognit* N2 deficit* S29 TX cognit* N2 deteriorat* S30 TX cognit* N2 declin* S31 TX cognit* N2 degenerat* S32 TX cognit* N2 complain*  S33 TX cognit* N2 disturb*  S34 TX cognit* N2 disorder* S35 TX memory N2 episod* or TX memory N2 los* or TX memory N2 impair* or TX memory N2 complain* S36 TX memory N2 disturb* or TX memory N2 disorder* or TX cerebr* N2 impair* or TX cerebr* N2 los*  S37 TX cerebr* N2 complain* or TX cerebr* N2 deteriorat* or TX cerebr* N2 disorder* or TX cerebr* N2 disturb*  S38 TX mental* N2 declin* or TX mental* N2 los* or TX mental* N2 impair* or TX mental* N2 deteriorat*  S39 TX "pre‐clinical dementia" or TX "preclinical dementia"  S40 or/1‐39 S41 TX huperz* S42 TX ayapin S43 TX scoparon* S44 S61 or S62 or S63 S45 S40 AND S44	1
6. ISI Web of Knowledge – all databases (includes: Web of Science (1945 to present); BIOSIS Previews (1926 to present); MEDLINE (1950 to present); Journal Citation Reports)	Topic=(mci OR "cognit* impair*" OR AAMI OR CIND OR SMC OR "episod* memory" OR "dement* prodrom*") AND Topic=(huperzi* OR ayapin* OR scoparon*) AND Topic=(trial OR RCT OR random* OR placebo OR "double‐blind*" OR "single‐blind*") Timespan=All Years. Databases=SCI‐EXPANDED, SSCI, A&HCI, CPCI‐S, CPCI‐SSH	14
7. LILACS (BIREME)	huperzine OR ayapin OR scoparon	1
8. CENTRAL (The Cochrane Library) (Issue 4 of 4, Oct 2010)	#1 "cognit* impair*" #2 MeSH descriptor Cognition Disorders explode all trees #3 MCI #4 ACMI #5 ARCD #6 SMC #7 CIND #8 BSF #9 AAMI #10 LCD #11 QD OR "questionable dementia" #12 AACD #13 MNCD #14 MCD #15 "N‐MCI" or "A‐MCI" or "M‐MCI" #16 (cognit* or memory or cerebr* or mental*) NEAR/3 (declin* or impair* or los* or deteriorat* or degenerat* or complain* or disturb* or disorder*) #17 "preclinical AD" #18 "pre‐clinical AD" #19 "preclinical alzheimer*" or "pre‐clinical alzheimer*" #20 aMCI OR MCIa #21 "CDR 0.5" OR "clinical dementia rating scale 0.5" #22 "GDS 3" OR "stage 3 GDS" #23 "global deterioration scale" AND "stage 3" #24 "Benign senescent forgetfulness" #25 "mild neurocognit* disorder*" #26 (prodrom* NEAR/2 dement*) #27 episodic* NEAR/2 memory #28 "preclinical dementia" OR "pre‐clinical dementia" #29 episodic NEAR/2 memory #30 "pre‐clinical dementia" OR "preclinical dementia" #31 (#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25 OR #26 OR #27 OR #28 OR #29 OR #30) #32 huperzi* OR ayapin* OR scoparon* #33 (#31 AND #32)	9
9. Clinicaltrials.gov (www.clinicaltrials.gov)	Keyword search: huperzine OR ayapin OR scoparon OR scoparone	7
10. ICTRP search portal (apps.who.int/trialsearch) (includes: Australian New Zealand Clinical Trials Registry; ClinicalTrilas.gov; ISRCTN; Chinese Clinical Trial Registry; Clinical Trials Registry – India; Clinical Research Information Service – Republic of Korea; German Clinical Trials Register; Iranian Registry of Clinical Trials; Japan Primary Registries Network; Pan African Clinical Trial Registry; Sri Lanka Clinical Trials Registry; The Netherlands National Trial Register)	Keyword search: huperzine OR ayapin OR scoparon	7
TOTAL before de‐duplication		582
TOTAL after de‐duplication and first assessment		4