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. 2016 Nov 7;2016(11):CD010690. doi: 10.1002/14651858.CD010690.pub2

Razazian 2015.

Methods
  • Study design: crossover RCT

Participants
  • Aged > 15 years

Interventions Treatment group 1
  • Capsules of gabapentin 200 mg after every HD for 4 weeks, 2 hours before sleep


Treatment group 2
  • Tablet of levodopa‐C 110 mg nightly 2 hours before sleep for 4 weeks

Outcomes
  • Severity of RLS

  • Severity of sleep disorder

  • QOL

  • Day time sleepiness

  • Drug adverse reaction

Notes
  • Some study data no longer accessible (figures and tables)

CGI ‐ Clinical Global Impressions; CKD ‐ chronic kidney disease; CVD ‐ cardiovascular disease; DBP ‐ diastolic blood pressure; ESKD ‐ end‐stage kidney disease; HD ‐ haemodialysis; IRLSSG ‐ International Restless Legs Syndrome Study Group Rating Scale; PD ‐ peritoneal dialysis; PLMI ‐ periodic limb movements index; PLMSAI ‐ Periodic Limb Movement During Sleep Arousal Index; PSQI ‐ Pittsburgh Sleep Quality Index; QOL ‐ quality of life; RCT ‐ randomised controlled trial; RLS ‐ restless legs syndrome; RLS‐6 ‐ Restless Legs‐6 Rating Scale; RLS‐QOL ‐ Restless Legs‐Quality of Life SBP ‐ systolic blood pressure