Comparison 2. Adverse events.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 At least one adverse event	5	556	Odds Ratio (M‐H, Fixed, 95% CI)	0.71 [0.44, 1.15]
2 At least one serious adverse event	3	418	Odds Ratio (M‐H, Fixed, 95% CI)	0.21 [0.01, 4.43]
3 Myopathy or myotoxicity	3	206	Odds Ratio (M‐H, Fixed, 95% CI)	0.33 [0.03, 3.28]
4 Liver dysfunction	5	551	Odds Ratio (M‐H, Fixed, 95% CI)	1.42 [0.27, 7.44]
5 Gastrointestinal symptoms	4	504	Odds Ratio (M‐H, Fixed, 95% CI)	1.17 [0.46, 3.00]
6 Sensitivity analysis: at least one adverse event	5	556	Risk Ratio (M‐H, Fixed, 95% CI)	0.78 [0.55, 1.11]
7 Sensitivity analysis: at least one serious adverse event	3	418	Risk Ratio (M‐H, Fixed, 95% CI)	0.21 [0.01, 4.41]
8 Sensitivity analysis. Myopathy or myotoxicity	3	206	Risk Ratio (M‐H, Fixed, 95% CI)	0.34 [0.04, 3.16]
9 Sensitivity analysis. Liver disfunction	5	551	Risk Ratio (M‐H, Fixed, 95% CI)	1.40 [0.28, 7.15]
10 Sensitivity analysis. Gastrointestinal symptoms	4	504	Risk Ratio (M‐H, Fixed, 95% CI)	1.16 [0.47, 2.87]