Paper title
Paper authors
Reviewer
Domain	Support for judgement	Review authors' judgement
Selection bias	Insert description, preferably a direct quote from report or correspondence, and add comment	One of : "Low risk", "High risk", "Unclear risk"
Random sequence generation	Describe the method used to generate the allocation sequence in sufficient detail to allow an assessment of whether it should produce comparable groups	Selection bias (biased allocation to interventions) due to inadequate generation of a randomised sequence
Allocation concealment	Describe the method used to conceal the allocation sequence in sufficient detail to determine whether intervention allocations could have been foreseen in advance of, or during, enrolment	Selection bias (biased allocation to interventions) due to inadequate concealment of allocations before assignment
Performance bias
Blinding of participants and personnel Assessments should be made for each main outcome (or class of outcomes)	Describe all measures used, if any, to blind study participants and personnel from knowledge of which intervention a participant received. Provide any information related to whether intended blinding was effective	Performance bias due to knowledge of allocated interventions by participants and personnel during the study
Detection bias
Blinding of outcome assessmentAssessments should be made for each main outcome (or class of outcomes)	Describe all measures used, if any, to blind outcome assessors from knowledge of which intervention a participant received. Provide any information related to whether intended blinding was effective	Detection bias due to knowledge of allocated interventions by outcome assessors
Attrition bias
Incomplete outcome dataAssessments should be made for each main outcome (or class of outcomes)	Describe completeness of outcome data for each main outcome, including attrition and exclusions from analysis. State whether attrition and exclusions were reported, numbers in each intervention group (compared with total randomised participants), reasons for attrition/exclusions when reported and any re‐inclusions in analyses performed by review authors	Attrition bias due to amount, nature or handling of incomplete outcome data
Reporting bias
Selective reporting	State how the possibility of selective outcome reporting was examined by the review authors, and what they found	Reporting bias due to selective outcome reporting
Other bias
Other sources of bias	State any important concerns about bias not addressed in other domains of the tool If particular questions/entries were pre‐specified in the review protocol, responses should be provided for each question/entry	Bias due to problems not covered elsewhere in the table