Summary of findings for the main comparison. NSAID compared with placebo for pain in women with endometriosis.
| NSAID compared with placebo for pain in women with endometriosis | ||||||
| Patient or population: women with endometriosis Setting: Finland Intervention: nonsteroidal anti‐inflammatory drugs (NSAIDs) Comparison: placebo | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | Number of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Risk with placebo | Risk with NSAID | |||||
| Pain relief assessed with: overall pain relief score follow‐up: median 2 months | 50 per 100 | 77 per 100 (38 to 95) | OR 3.27 (0.61 to 17.69) | 24 (1 RCT) | ⊕⊝⊝⊝ Very lowa,b | |
| Unintended effects from treatment follow‐up: median 2 months | 58 per 100 | 39 per 100 (11 to 78) | OR 0.46 (0.09 to 2.47) | 24 (1 RCT) | ⊕⊝⊝⊝ Very lowa,b | |
| Quality of life: not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Effects on daily activities: not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Absence from work or school: not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Number of women requiring more invasive treatment: not reported | ‐ | ‐ | ‐ | ‐ | ‐ | |
| Requirements for additional medication follow‐up: median 2 months | 83 per 100 | 38 per 100 (5 to 87) | OR 0.12 (0.01 to 1.29) | 24 (1 RCT) | ⊕⊝⊝⊝ Very lowa,b | |
| Participant satisfaction with treatment: not reported | ||||||
| *The risk in the intervention group (and its 95% confidence interval) is based on assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; OR: odds ratio. | ||||||
| GRADE Working Group grades of evidence. High quality: We are very confident that the true effect lies close to the estimate of effect. Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of effect but may be substantially different. Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of effect. Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect. | ||||||
aDowngraded one level owing to overall unclear risk of bias for included trial.
bDowngraded two levels for imprecision because confidence interval is wide, consistent with benefit and harm and evidence based on a single small trial.