Nguyen 2008.

Methods	Single‐centre RCT on anterior vaginal prolapse CONSORT statement: yes Power calculation: 38 in each arm Type of randomisation: computer generated Blinding strategy: primary surgeon ‐ until the surgery day; patients, research nurse and medical assistant remained blinded Allocation concealment: sealed opaque envelopes Definition of cure Anterior wall POPQ at stage < 2, ‘Optimal support’ = Aa and Ba at stage 0, ‘Satisfactory’ = Aa and Ba at stage 1 and improved from preop staging Follow‐up: 12 months (full publication) and 24 months (abstract only) Prolapse assessment: POPQ
Participants	Inclusion: 21 years old and older with POPQ stage 2 or greater anterior prolapse requiring surgical correction Exclusion: pregnancy (present or contemplated), prior repair with graft, systemic infection, compromised immune system, uncontrolled diabetes mellitus, previous pelvic irradiation/cancer, polypropylene allergy, scheduled for concomitant Burch or pubovaginal sling Randomised: 76 Withdrawal: 1 Lost to follow‐up: 1 Analysed: 76
Interventions	A (38): anterior colporrhaphy (AC) with delayed absorbable (PDS) sutures B (38): AC + polypropylene 4‐armed mesh kit repair (Perigee, American Medical Systems) Concomitant surgery: vaginal hysterectomy, bilateral salpingo‐oophorectomy, uterosacral suspension, mid‐urethral tape, site‐specific rectocele repair, perineoplasty, Apogee mesh kit repair Concomitant prolapse and suburethral tape surgeries were performed in both groups
Outcomes	Assessed at 1 year Reported the following review outcomes at 1 year Repeat prolapse surgery Recurrent prolapse (anterior prolapse stage 2 or greater) Death (no events) Mesh exposure Objective failure of anterior compartment POPQ assessment of prolapse: points Ba, C, Bp; vaginal length (reported median and range) Sexual function: de novo dyspareunia; PISQ Quality of life: PFIQ (and other measures) ‐ end scores Operating time (median and range) Blood transfusion Days in hospital (median and range)
Notes	Data regarding study methods were obtained from the full published article, with follow‐up at 12 months PFDI ‐ Pelvic Floor Distress Inventory (quality of life measure) PFIQ ‐ Pelvic Floor Incontinence Questionnaire (quality of life measure)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated randomisation
Allocation concealment (selection bias)	Low risk	Sealed opaque envelopes
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Participants blinded
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Assessors blinded; participant‐completed questionnaires
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Data set complete: AC 37/38, mesh 37/38
Selective reporting (reporting bias)	Low risk	Significant outcome data
Other bias	Unclear risk	No statement