Common 1976.

Methods	Allocation: random Single blind Exclusions after randomisation: nil Losses to follow‐up: 23 at 7 months
Participants	Country: USA Participants: 50 Age: > 18 years Sex: Male and female Inclusion criteria: venographically confirmed DVT duration < 14 days Exclusion criteria: pregnancy; surgery or childbirth < 10 days; bleeding dysfunction; peptic ulcer; recent streptococcal infection; active TB; carotid bruit; stroke < 6 months; diastolic BP > 100 mmHg; atrial fibrillation; hypertensive retinopathy grade 3/4; hepatic/renal biopsy aortography < 14 days
Interventions	Treatment: hydrocortisone 100 mg IV then streptokinase IV 250,000 U over 30 minutes, then 100,000 U/hour titrated for 72 hours. Followed by IV heparin titrated over 7 days Control: IV heparin 150 U/kg loading dose then titrated for 10 days Co‐treatment: warfarin given from day 6 ‐ 7
Outcomes	3 ‐ 10 days: clot lysis; bleeding; stroke; mortality 7 months: clot lysis
Notes	Did not specify whether arm vein thrombosis included or not
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	stated "randomized" but no further details given
Allocation concealment (selection bias)	Unclear risk	not described
Blinding of participants and personnel (performance bias) All outcomes	Low risk	not described but judged as low risk of bias as outcome assessment blinding described
Blinding of outcome assessment (detection bias) All outcomes	Low risk	"..two radiologists who were unaware of the patient's treatment were evaluated the venograms..."
Incomplete outcome data (attrition bias) All outcomes	Low risk	no missing data
Selective reporting (reporting bias)	Low risk	all outcomes reported
Other bias	Low risk	none